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[texts]The FGF2 gene in a myopia animal model and human subjects. (Volume 18) - An, Jianhong
This article is from Molecular Vision, volume 18.AbstractPurpose: Fibroblast growth factor-2 (FGF2) has been implied in the development of myopia according to previous studies investigating FGF2 in the sclera and retinal pigment epithelium. This study measured retinal FGF2 gene expression in an animal model and also tested for the association between single nucleotide polymorphisms (SNPs) in FGF2 and high myopia...
Downloads: 1
[texts]TECHNICAL BRIEF: Optimized pipeline for isolation of high-quality RNA from corneal cell subpopulations. (Volume 20) - Bath, Chris
This article is from Molecular Vision, volume 20.AbstractPurpose: Attempts to determine the transcriptional profile of discrete subsets of limbal epithelial cells in situ using laser capture microdissection (LCM) face two major challenges. First, the transcriptional profile of cells within a tissue may rapidly change as the tissue is excised and exposed to cold ischemia. Second, there is a risk of degradation of the RNA as the cellular compartment is separated from the remaining tissue...
Downloads: 2
[texts]Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G>A and Leber hereditary optic neuropathy. (Volume 18) - Bi, Rui
This article is from Molecular Vision, volume 18.AbstractPurpose: The majority of Leber hereditary optic neuropathy (LHON) cases are caused by one of three mitochondrial DNA (mtDNA) primary mutations (m.3460G>A, m.11778G>A, and m.14484T>C). In recent studies, we and others have shown that mutation m.3635G>A is a primary LHON mutation, particularly in Chinese. The purpose of this study was to perform a thorough analysis for the complete mtDNA genome sequence variation in Chinese patients with m.3...
Downloads: 4
[texts]Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population. (Volume 18) - Buentello-Volante, Beatriz
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the association of age-related macular degeneration (AMD)–high risk alleles of the complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), complement component 3 (C3), and age-related maculopathy susceptibility 2 (ARMS2) genes in a Mexican population for the first time. Methods: Genotyping was performed for the Y402H variant of CFH, for the L9H, R32Q, and K565E variants of CFB, the E318D...
Downloads: 4
[texts]Familial discordance in Stargardt disease. (Volume 18) - Burke, Tomas R.
This article is from Molecular Vision, volume 18.AbstractPurpose: To report genetic and phenotypic discordance across two generations of a family with autosomal recessive Stargardt disease (STGD1) and to compare pathogenicities of the G1961E and A1038V alleles of the ATP-binding cassette transporter, subfamily A, member 4 (ABCA4) gene. Methods: Five members of a family with STGD1 (patients 1–4, affected; patient 5, carrier) were included...
Downloads: 5
[texts]Quinotrierixin inhibits proliferation of human retinal pigment epithelial cells. (Volume 19) - Chen, Chen
This article is from Molecular Vision, volume 19.AbstractPurpose: To investigate the effect of quinotrierixin, a previously reported inhibitor of X-box binding protein 1 (XBP1), on cell proliferation and viability in human retinal pigment epithelium (RPE) cells. Methods: Subconfluent human RPE cells (ARPE-19) were exposed to quinotrierixin for 16–24 h. Cell proliferation was determined with 3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay, hemocytometer counts, and CyQUANT NF...
Downloads: 1
[texts]A novel PAX6 deletion in a Chinese family with congenital aniridia. (Volume 18) - Chen, Jian Huan
This article is from Molecular Vision, volume 18.AbstractPurpose: To identify a disease-causing paired box 6 (PAX6) gene mutation in a Chinese family affected by autosomal dominant congenital aniridia. Methods: All participants in the study, including the aniridia family and 100 unrelated senile cataract controls, received a comprehensive ophthalmic examination. Genomic DNA was extracted from their whole blood...
Downloads: 4
[texts]Endophenotyping reveals differential phenotype-genotype correlations between myopia-associated polymorphisms and eye biometric parameters. (Volume 18) - Chen, Jian Huan
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the association with ocular biometric parameters in myopia-associated single nucleotide polymorphisms (SNPs) of the gap junction protein delta 2 (GJD2), insulin-like growth factor-1 (IGF1) and hepatocyte growth factor (HGF) genes in two geographically different Chinese cohorts. Methods: In 814 unrelated Han Chinese individuals aged above 50 years including 362 inland residents and 432 island dwellers, comprehensive ...
Downloads: 2
[texts]No association of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 or complement factor H polymorphisms with early age-related maculopathy in a Chinese cohort. (Volume 19) - Chen, Jian-Huan
This article is from Molecular Vision, volume 19.AbstractPurpose: Single nucleotide polymorphisms (SNPs) of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 (ARMS2/HTRA1) and complement factor H (CFH) have been reported to be associated with age-related macular degeneration (AMD). The purpose of this study was to investigate the association of ARMS2/HTRA1 and CFH SNPs with early age-related maculopathy (ARM) in a Han Chinese cohort...
Downloads: 3
[texts]Novel mutations of the RS1 gene in a cohort of Chinese families with X-linked retinoschisis. (Volume 20) - Chen, Jieqiong
This article is from Molecular Vision, volume 20.AbstractPurpose: X-linked retinoschisis is a retinal dystrophy caused by mutations in the RS1 gene in Xp22.1. These mutations lead to schisis (splitting) of the neural retina and subsequent reduction in visual acuity in affected men (OMIM # 312700). The aim of this study was to identify the RS1 gene mutations in a cohort of Chinese patients with X-linked retinoschisis, and to describe the associated phenotypes...
Downloads: 6
[texts]Lithium chloride promotes host resistance against Pseudomonas aeruginosa keratitis. (Volume 19) - Chen, Kang
This article is from Molecular Vision, volume 19.AbstractPurpose: To explore the role of lithium chloride (LiCl) in Pseudomonas aeruginosa (PA) keratitis. Methods: B6 mice were subconjunctivally injected with LiCl in contrast to appropriate control sodium chloride (NaCl), and then routinely infected with PA. Clinical score, slit-lamp photography, hematoxylin and eosin (H&E) staining, and bacterial plate counts were used to determine the role of LiCl in PA keratitis...
Downloads: 3
[texts]SNP rs1533428 at 2p16.3 as a marker for late-onset primary open-angle glaucoma. (Volume 18) - Chen, Li Jia
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the associations between gene variants in cholesterol 24S-hydroxylase (CYP46A1), LIM homeobox transcription factor 1-beta (LMX1B), plexin domain containing 2 (PLXDC2), toll-like receptor 4 (TLR4), transmembrane and tetratricopeptide repeat containing 2 (TMTC2), zona pellucida glycoprotein 4 (ZP4), chromosome 2p16.3, and primary open-angle glaucoma (POAG)...
Downloads: 1
[texts]Mutation analysis of paired box 6 gene in inherited aniridia in northern China. (Volume 19) - Chen, Peng
This article is from Molecular Vision, volume 19.AbstractPurpose: Aniridia is phenotypically and genetically heterogeneous. This study is to summarize the phenotypes and identify the underlying genetic cause of the paired box 6 (PAX6) gene responsible for aniridia in two three-generation Chinese families in northern China. Methods: A detailed family history and clinical data were collected from patients during an ophthalmologic examination...
Downloads: 4
[texts]Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy. (Volume 19) - Chen, Yabin
This article is from Molecular Vision, volume 19.AbstractPurpose: Dominant optic atrophy (DOA) is the most common form of autosomal inherited optic neuropathy, mainly caused by mutations in the optic atrophy 1 (OPA1) gene. The purpose of this study was to detect OPA1 gene mutations and associated phenotypes in Chinese patients with suspected hereditary optic neuropathy. Methods: A cohort of 193 Chinese families with suspected hereditary optic neuropathy was collected, which had been excluded fro...
Downloads: 3
[texts]Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation. (Volume 20) - Couturier, Aude
This article is from Molecular Vision, volume 20.AbstractPurpose: To evaluate whether anti-vascular endothelial growth factor (VEGF) neutralizing antibodies injected in the vitreous of rat eyes influence retinal microglia and macrophage activation. To dissociate the effect of anti-VEGF on microglia and macrophages subsequent to its antiangiogenic effect, we chose a model of acute intraocular inflammation...
Downloads: 9
[texts]ADP-ribosylation factor as a novel target for corneal neovascularization regression. (Volume 18) - Dai, Chunyan
This article is from Molecular Vision, volume 18.AbstractPurpose: To evaluate the roles of ADP-ribosylation factor (ARF) in alkali-induced corneal neovascularization (CNV). Methods: CNV was induced by alkali injury and compared in ARF1 inhibitor– or vehicle-treated mice 3 weeks after injury. Angiogenic and apoptosis factor expression in corneas after injury was quantified with reverse-transcription PCR...
Downloads: 3
[texts]Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs. (Volume 17) - Dong, Feng
This article is from Molecular Vision, volume 17.AbstractPurpose: The dopamine (DA) system in the retina is critical to normal visual development as lack of retinal DA signaling may contribute to myopic development. The involvement of DA in myopic development is complex and may be different between form deprivation and hyperopic defocus. This study evaluated effects of a non-selective DA receptor agonist, apomorphine (APO) on refractive development in guinea pigs treated with form deprivation o...
Downloads: 4
[texts]Heat shock protein 70 expression induced by diode laser irradiation on choroid-retinal endothelial cells in vitro. (Volume 18) - Du, Shanshan
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the biologic effect of an 810 nm diode laser on the induction of heat shock protein 70 (Hsp70) in choroid-retinal endothelial cells in vitro. Methods: Cultured rhesus macaque choroid-retinal endothelial cells (RF/6A) were irradiated using an 810 nm diode laser (spot size, 10 mm; duration, 60 s; power, 400–1,500 mW). Cell viability was assessed by annexin V- fluorescein isothiocyanate (FITC) and propidium iodide f...
Downloads: 8
[texts]Endothelial nitric oxide synthase polymorphisms and susceptibility to high-tension primary open-angle glaucoma in an Egyptian cohort. (Volume 20) - Emam, Wafaa A.
This article is from Molecular Vision, volume 20.AbstractPurpose: To analyze the association of polymorphisms of the endothelial nitric oxide synthase (NOS3) gene and nitric oxide (NO) levels with high-tension primary open-angle glaucoma (POAG) in an Egyptian population. Methods: This case-control study included 160 patients who had high-tension POAG (76 men and 84 women; age range 41–75 years) and 110 controls (56 men and 54 women; age range 55–78 years)...
Downloads: 4
[texts]Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. (Volume 20) - Fan, Qi
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. Methods: The active full-length CRYAA protein corresponding to amino acids 1–173 of CRYAA was recombined. A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tag...
Downloads: 1
[texts]Identification of two novel LRP5 mutations in families with familial exudative vitreoretinopathy. (Volume 20) - Fei, Ping
This article is from Molecular Vision, volume 20.AbstractPurpose: To investigate the clinical features and disease-causing mutations in two Chinese families with familial exudative vitreoretinopathy (FEVR). Methods: Clinical data and genomic DNA were collected for patients with FEVR. The coding exons and adjacent intronic regions of FZD4, LRP5, TSPAN12, and NDP were amplified with PCR, and the resulting amplicons were analyzed with Sanger sequencing...
Downloads: 3
[texts]Azithromycin reduces inflammation in a rat model of acute conjunctivitis. (Volume 19) - Fernandez-Robredo, Patricia
This article is from Molecular Vision, volume 19.AbstractPurpose: Macrolide antibiotics are known to have various anti-inflammatory effects in addition to their antimicrobial activity, but the mechanisms are still unclear. The effect of azithromycin on inflammatory molecules in the lipopolysaccharide-induced rat conjunctivitis model was investigated. Methods: Twenty-four Wistar rats were divided into two groups receiving topical ocular azithromycin (15 mg/g) or vehicle...
Downloads: 2
[texts]Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium. (Volume 20) - Fu, Shuhua
This article is from Molecular Vision, volume 20.AbstractPurpose: To dissect gene functions in the retinal pigment epithelium (RPE), we previously generated a tetracycline-inducible RPE-specific Cre mouse line. Although this Cre mouse line was useful for several conditional gene targeting studies that were conducted by different laboratories, its potential has not been fully exploited, presumably due to a lack of knowledge or procedure for inducing Cre expression appropriately in this mouse line...
[texts]Evaluation of MMP2 as a candidate gene for high myopia. (Volume 19) - Gong, Bo
This article is from Molecular Vision, volume 19.AbstractPurpose: Matrix metalloproteinase 2 (MMP2) has been shown to be expressed in the human sclera, and is increased in the sclera of the eye with myopia induced by form deprivation in chicks when compared with the control eye. The purpose of this study was to examine the relationship between high myopia and MMP2 in a mainland Han Chinese population...
Downloads: 5
[texts]Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1. (Volume 18) - Ha, Yonju
This article is from Molecular Vision, volume 18.AbstractPurpose: Sigma receptor 1 (σR1) is a non-opioid transmembrane protein that may act as a molecular chaperone at the endoplasmic reticulum–mitochondrial membrane. Ligands for σR1, such as (+)-pentazocine [(+)-PTZ], confer marked retinal neuroprotection in vivo and in vitro. Recently we analyzed the retinal phenotype of mice lacking σR1 (σR1 KO) and observed normal retinal morphology and function in young mice (5–30 weeks) but diminis...
Downloads: 2
[texts]The crucial role of collagen-binding integrins in maintaining the mechanical properties of human scleral fibroblasts-seeded collagen matrix. (Volume 17) - Hu, Shoulong
This article is from Molecular Vision, volume 17.AbstractPurpose: The aim of this study was to identify the presence of collagen-binding integrin subunits in human scleral fibroblasts (HSFs) and investigate their actual functions in maintaining the mechanical creep properties of the HSFs-seeded collagen matrix. Methods: Primary HSFs were cultured in vitro. Reverse- transcription PCR was used to detect mRNA expression of integrin α1, α2, and β1 subunits in HSFs...
Downloads: 3
[texts]A novel splicing mutation of the FRMD7 gene in a Chinese family with X-linked congenital nystagmus. (Volume 18) - Hu, Ying
This article is from Molecular Vision, volume 18.AbstractPurpose: To identify a potential pathogenic mutation in a four-generation Chinese family with X-linked congenital nystagmus (XLCN). Methods: Routine clinical examination and ophthalmic evaluation were performed on normal controls, two patients and two healthy members of the family. Genomic DNA was prepared from the peripheral blood of members of the family and from 50 normal controls...
Downloads: 3
[texts]Adeno-associated virus-mediated expression of growth-associated protein-43 aggravates retinal ganglion cell death in experimental chronic glaucomatous injury. (Volume 19) - Huang, Chukai
This article is from Molecular Vision, volume 19.AbstractPurpose: To examine whether adeno-associated virus (AAV) vector-mediated overexpression of growth-associated protein-43 (GAP-43) has protective or deleterious effects on retinal ganglion cell (RGC) survival in laser-induced chronic intraocular pressure (IOP) elevation injury. Methods: Adult Fischer 344 rats received unilateral intravitreal injection of either normal saline, AAV-green fluorescent protein (AAV-GFP), or a bicistronic AAV vect...
Downloads: 1
[texts]A Chinese family with Oguchi's disease due to compound heterozygosity including a novel deletion in the arrestin gene. (Volume 18) - Huang, Lingli
This article is from Molecular Vision, volume 18.AbstractPurpose: Oguchi’s disease is a rare autosomal recessive disease and known to be caused by mutations in the rhodopsin kinase (GRK1) gene or the arrestin (SAG) gene. SAG contains 16 exons and encodes a protein with 405 amino acids. This study was to identify the underlying genetic defects in a non-consanguineous Chinese family with Oguchi’s disease...
Downloads: 1
[texts]Comparison of ophthalmic sponges and extraction buffers for quantifying cytokine profiles in tears using Luminex technology. (Volume 18) - Inic-Kanada, Aleksandra
This article is from Molecular Vision, volume 18.AbstractPurpose: Evaluating cytokine profiles in tears could shed light on the pathogenesis of various ocular surface diseases. When collecting tears with the methods currently available, it is often not possible to avoid the tear reflex, which may give a different cytokine profile compared to basal tears. More importantly, tear collection with glass capillaries, the most widely used method for taking samples and the best method for avoiding tear ...
Downloads: 4
[texts]A standard Bible dictionary ; designed as a comprehensive guide to the scriptures, embracing their languages, literature, history, biography, manners and customs, and their theology - Jacobus, Melancthon Williams, 1855-1937
Electronic reproduction
Keywords: Bible
Downloads: 352
[texts]p38 mitogen-activated protein kinase-induced nuclear factor kappa-light-chain-enhancer of activated B cell activity is required for neuroprotection in retinal ischemia/reperfusion injury. (Volume 18) - Jiang, Shao-Yun
This article is from Molecular Vision, volume 18.AbstractPurpose: In our previous study, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) played a neuroprotective role in retinal ischemia/reperfusion (I/R) injury in rats. However, the mechanism of NF-κB neuroprotection is still unclear. We hypothesize that p38 mitogen-activated protein kinase (MAPK) is expressed and NF-κB activity induced by p38 MAPK plays a neuroprotective role through antiapoptotic genes (B-cell lympho...
Downloads: 3
[texts]?1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo. (Volume 20) - Jiang, Youde
This article is from Molecular Vision, volume 20.AbstractPurpose: Determine whether Compound 49b treatment ameliorates retinal changes due to the lack of β2-adrenergic receptor signaling. Methods: Using retinas from 3-month-old β2-adrenergic receptor-deficient mice, we treated mice with our novel β1-/β2-adrenergic receptor agonist, Compound 49b, to assess the effects of adrenergic agonists acting only on β1-adrenergic receptors due to the absence of β2-adrenergic receptors...
Downloads: 12
[texts]Familial aggregation of primary open angle glaucoma in Shanghai, China. (Volume 19) - Kong, Xiangmei
This article is from Molecular Vision, volume 19.AbstractPurpose: To identify familial aggregation of primary open angle glaucoma (POAG) in first-degree relatives in Shanghai, China. Methods: This was a prospective case-control study. First-degree relatives of 113 POAG patients and 119 normal controls underwent a standardized ophthalmic examination. Each participant was diagnosed as normal, glaucoma suspect or glaucoma...
Downloads: 3
[texts]Phase contrast microscopy of living cells within the whole lens: spatial correlations and morphological dynamics. (Volume 18) - Kong, Zhiying
This article is from Molecular Vision, volume 18.AbstractPurpose: Images from cultured lens cells do not convey enough spatial information, and imaging of fixed lens specimens cannot reveal dynamic changes in the cells. As such, a real-time, convenient approach for monitoring label-free imaging of dynamic processes of living cells within the whole lens is urgently needed. Methods: Female Wistar rat lenses were kept in organ culture...
Downloads: 5
[texts]The D1 dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. (Volume 18) - Li, Guang-Yu
This article is from Molecular Vision, volume 18.AbstractPurpose: Oxidative stress is widely implicated in the death of retinal ganglion cells associated with various optic neuropathies. Agonists of the dopamine D1 receptor have recently been found to be potentially neuroprotective against oxidative stress–induced injury. The goal of this study was to investigate whether SKF83959, a next-generation high-affinity D1 receptor agonist, could protect retinal ganglion cell 5 (RGC-5) cells from H2O2...
Downloads: 1
[texts]The proliferation of malignant melanoma cells could be inhibited by ranibizumab via antagonizing VEGF through VEGFR1. (Volume 20) - Li, Jiao
This article is from Molecular Vision, volume 20.AbstractPurpose: Angiogenesis is an important mediator in tumor progression. Vascular endothelial growth factor (VEGF) is one of the major cytokines that can influence angiogenesis. However, the potential mechanism of tumor growth inhibition through anti-VEGF agents is still unclear. This study was performed to examine whether ranibizumab could inhibit malignant melanoma growth in vitro and to determine the safety of ranibizumab on human adult ret...
Downloads: 3
[texts]Calcium entry mediates hyperglycemia-induced apoptosis through Ca2+/calmodulin-dependent kinase ll in retinal capillary endothelial cells. (Volume 18) - Li, Jun
This article is from Molecular Vision, volume 18.AbstractPurpose: Hyperglycemia-induced vascular cell apoptosis is a seminal early event in diabetic retinopathy. Prolonged hyperglycemia is known to increase intracellular cytosolic free calcium ([Ca2+]i) in retinal vascular endothelial cells (RECs), suggesting that [Ca2+]i is a critical trigger for microvascular degeneration. This study aims to elucidate Ca2+-dependent signaling mechanisms that mediate hyperglycemia-induced apoptosis in RECs...
Downloads: 2
[texts]Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt. (Volume 19) - Li, Zhongrui
This article is from Molecular Vision, volume 19.AbstractPurpose: Oxidative stress on retinal pigment epithelial (RPE) cells is thought to play a crucial role in the development and progression of age-related macular degeneration. Astaxanthin (AST) is a carotenoid that shows significant antioxidant properties. This study was designed to investigate the protective effect of AST on ARPE-19 cells against oxidative stress and the possible underlying mechanism...
Downloads: 3
[texts]Ala344Pro mutation in the FGFR2 gene and related clinical findings in one Chinese family with Crouzon syndrome. (Volume 18) - Lin, Ying
This article is from Molecular Vision, volume 18.AbstractPurpose: The purpose of this study was to investigate the fibroblast growth factor receptor 2 (FGFR2) gene in three Chinese patients with Crouzon syndrome and to characterize the related clinical features. Methods: A single family underwent complete ophthalmic examinations, and three patients were diagnosed with Crouzon syndrome. Genomic DNA was extracted from leukocytes of peripheral blood collected from members of the family as well as f...
Downloads: 3
[texts]Maternal germline mosaicism of kinesin family member 21A (KIF21A) mutation causes complex phenotypes in a Chinese family with congenital fibrosis of the extraocular muscles. (Volume 20) - Liu, Gang
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify the causative mutation with its possible origin in a Chinese family with congenital fibrosis of extraocular muscles type 1 (CFEOM1) and to characterize the ocular phenotypes and lesions in the corresponding intracranial nerves. Methods: Three affected siblings and their asymptomatic parents underwent comprehensive ophthalmic examinations and neuropathologic analysis involving magnetic resonance imaging (MRI)...
Downloads: 3
[texts]Critical role of SDF-1?-induced progenitor cell recruitment and macrophage VEGF production in the experimental corneal neovascularization. (Volume 17) - Liu, Gaoqin
This article is from Molecular Vision, volume 17.AbstractPurpose: To address the roles of the stromal derived factor-1 (SDF-1) α in the course of experimental corneal neovascularization (CNV). Methods: CNV was induced by alkali injury and compared in SDF-1α- or vehicle-treated mice two weeks after injury. Angiogenic factor expression in the early phase after injury was quantified by reverse transcription polymerase chain reaction (RT-PCR)...
Downloads: 1
[texts]Polymorphism in the 11q24.1 genomic region is associated with myopia: A comprehensive genetic study in Chinese and Japanese populations. (Volume 20) - Liu, Jie
This article is from Molecular Vision, volume 20.AbstractPurpose: To evaluate the association of polymorphisms in the 11q24.1 genomic region and the CTNND2 gene with myopia. Methods: We conducted a comprehensive meta-analysis included 6,954 cases and 9,346 controls. Odds ratios (ORs) were calculated using Carlin’s method. Publication bias was assessed using Egger et al.’s approach. Sensitivity, heterogeneity, and trim and fill analyses were also conducted...
Downloads: 1
[texts]Amniotic membrane traps and induces apoptosis of inflammatory cells in ocular surface chemical burn. (Volume 18) - Liu, Ting
This article is from Molecular Vision, volume 18.AbstractPurpose: Severe chemical burns can cause necrosis of ocular surface tissues following the infiltration of inflammatory cells. It has been shown that amniotic membrane transplantation (AMT) is an effective treatment for severe chemical burns, but the phenotypes of cells that infiltrate the amniotic membrane and the clinical significance of these cellular infiltrations have not previously been reported...
Downloads: 5
[texts]The role of lysyl oxidase-like 1 DNA copy number variants in exfoliation glaucoma. (Volume 18) - Liu, Yutao
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate whether DNA copy number variants (CNVs) in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) in black South Africans. Methods: Black South African subjects with XFG and age-matched unaffected controls were recruited from the St. John Eye Hospital in Soweto (Johannesburg, South Africa) and East London Hospital Complex (Eastern Cape, South Africa) using standard clinical examination ...
Downloads: 3
[texts]Notch signaling promotes the corneal epithelium wound healing. (Volume 18) - Lu, Huayi
This article is from Molecular Vision, volume 18.AbstractPurpose: The Notch signaling pathway plays crucial roles in regulation of cell proliferation, differentiation and cell fate decision in multiple tissues and cell types. This study was designed to test the effects of enhanced Notch activity on corneal epithelium homeostasis and wound healing using the transgenic mice that overexpressed an activated Notch1 (NICD) in cornea epithelium...
Downloads: 3
[texts]Murine corneal stroma cells inhibit LPS-induced dendritic cell maturation partially through TGF-?2 secretion in vitro. (Volume 18) - Lu, Jian-Min
This article is from Molecular Vision, volume 18.AbstractPurpose: The peripheral cornea contains mature and immature resident dendritic cells (DCs) while the central cornea is exclusively equipped with immature DCs. There must be some factors that cause immature DCs. This study investigated whether corneal stroma cells (CSCs) inhibit DC maturation by secreting cytokines. Methods: The messenger ribonucleic acid (mRNA) and protein level of transforming growth factor beta 2 (TGF-β2) was analyzed u...
Downloads: 2
[texts]Meta-analysis of association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-?2 gene and diabetic retinopathy in Caucasians and Asians. (Volume 18) - Ma, Jinlan
This article is from Molecular Vision, volume 18.AbstractPurpose: The Pro12Ala polymorphism of the peroxisome proliferator–activated receptor-γ2 (PPARγ2) gene is reported to be associated with diabetes. However, the gene’s association with diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) has been investigated in numerous epidemiologic studies with controversial results. This meta-analysis aimed to collectively assess the association of the Pro12Ala polymorphism with DR in T2DM...
Downloads: 2
[texts]Molecular profiling of complete congenital stationary night blindness: A pilot study on an Indian cohort. (Volume 20) - Malaichamy, Sivasankar
This article is from Molecular Vision, volume 20.AbstractPurpose: Congenital stationary night blindness (CSNB) is a non-progressive retinal disorder that shows genetic and clinical heterogeneity. CSNB is inherited as an autosomal recessive, autosomal dominant, or X-linked recessive trait and shows a good genotype–phenotype correlation. Clinically, CSNB is classified as the Riggs type and the Schubert-Bornschein type...
Downloads: 2
[texts]Proteomic analysis of SRA01/04 transfected with wild-type and mutant HSF4b identified from a Chinese congenital cataract family. (Volume 18) - Miao, Aizhu
This article is from Molecular Vision, volume 18.AbstractPurpose: Congenital cataracts account for about 10% of cases of childhood blindness. Heat shock transcription factor 4 (HSF4) is related with human autosomal dominant lamellar and Marner cataracts; a T→C transition at nucleotide 348 was found in a large Chinese cataract family. The aim of this study was to analyze the unique role of HSF4b and the mutation of HSF4b...
Downloads: 1
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